@inbook{b7a6a2db3108459f8c2f83acea9f51c2,
title = "Chapter Four Methods to Analyze the Palmitoylated CD95 High Molecular Weight Death-Inducing Signaling Complex",
abstract = "Major work elucidating the structure and function of the CD95 death inducing signaling complex (DISC) was carried in the late 1990s. Since then the DISC has become a paradigm for multiprotein signaling complexes in the apoptosis literature. We analyzed the earliest events of DISC formation with a set of different techniques and found a surprising new characteristic of the CD95 DISC. Data revealed that CD95 is palmitoylated on cysteine 199. This lipid modification enhances receptor aggregation to the high molecular weight DISC.",
author = "Christine Feig and Peter, {Marcus E.}",
note = "Funding Information: The work was supported by the National Institutes of Health (R01 CA93519).",
year = "2008",
doi = "10.1016/S0076-6879(08)01404-3",
language = "English (US)",
isbn = "9780123743121",
series = "Methods in Enzymology",
pages = "83--100",
editor = "Roya Khosravi-Far and Zahra Zakeri and Richard Lockshin and Mauro Piacentini",
booktitle = "Programmed Cell Death,General Principles forStudying Cell Death, Part A",
}