Characterisation of the effects of ATPA, a GLUK5 receptor selective agonist, on excitatory synaptic transmission in area CA1 of rat hippocampal slices

V. R.J. Clarke*, G. L. Collingridge

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Kainate receptors are involved in a variety of synaptic functions in the CNS including the regulation of excitatory synaptic transmission. Previously we described the depressant action of the GLUK5 selective agonist (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid (ATPA) on synaptic transmission in the Schaffer collateral-commissural pathway of rat hippocampal slices. In the present study we report several new features of the actions of ATPA at this synapse. Firstly, the effectiveness of ATPA is developmentally regulated. Secondly, the effects of ATPA decline during prolonged or repeated applications. Thirdly, the effects of ATPA are not mediated indirectly via activation of GABAA, GABAB, muscarinic or adenosine A1 receptors. Fourthly, elevating extracellular Ca2+ from 2 to 4 mM antagonises the effects of ATPA. Some differences between the actions of ATPA and kainate on synaptic transmission in the Schaffer collateral-commissural pathway are also noted.

Original languageEnglish (US)
Pages (from-to)889-902
Number of pages14
JournalNeuropharmacology
Volume42
Issue number7
DOIs
StatePublished - 2002

Keywords

  • ATPA
  • EPSP
  • GLUK5 receptors
  • Hippocampus
  • Kainate receptors
  • LY382884

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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