TY - JOUR
T1 - Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)
AU - Mascioli, Stephen R.
AU - Grimm, Richard H.
AU - Neaton, James D.
AU - Stamler, Jeremiah
AU - Prineas, Ronald J.
AU - Cutler, Jeffrey A.
AU - Elmer, Patricia J.
AU - McDonald, Robert
AU - Schnaper, Harold
AU - Schoenberger, James
N1 - Funding Information:
From the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota. This study is being supported in part by a grant from the National Heart, Lung, and Blood Institute, Beth&a, Maryland, and grants from Boehringer Ingelheim Pharmaceuticals, Inc., Merck Sharp and Dohme, Pfizer Pharmaceuticals. and Wyeth-Aycrst Laboratories.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1990/9/25
Y1 - 1990/9/25
N2 - The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.
AB - The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.
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U2 - 10.1016/0002-9149(90)90760-X
DO - 10.1016/0002-9149(90)90760-X
M3 - Article
C2 - 2220647
AN - SCOPUS:0025130037
SN - 0002-9149
VL - 66
SP - C32-C35
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 9
ER -