Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS)

Stephen R. Mascioli, Richard H. Grimm*, James D. Neaton, Jeremiah Stamler, Ronald J. Prineas, Jeffrey A. Cutler, Patricia J. Elmer, Robert McDonald, Harold Schnaper, James Schoenberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (β blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) dpxazosin (α1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.

Original languageEnglish (US)
Pages (from-to)C32-C35
JournalThe American journal of cardiology
Issue number9
StatePublished - Sep 25 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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