TY - JOUR
T1 - Characterization of a murine Ahr null allele
T2 - Involvement of the Ah receptor in hepatic growth and development
AU - Schmidt, Jennifer V.
AU - Su, Gloria Huei Ting
AU - Reddy, Janardan K.
AU - Simon, M. Celeste
AU - Bradfield, Christopher A.
PY - 1996/6/25
Y1 - 1996/6/25
N2 - The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. In an effort to gain insight into the physiological role of the AHR and to develop models useful in risk assessment, gene targeting was used to inactivate the murine Ahr gene by homologous recombination. Ahr(-/-) mice are viable and fertile but show a spectrum of hepatic defects thai indicate a role for the AHR in normal liver growth and development. The Ahr(-/-) phenotype is most severe between 0-3 weeks of age and involves slowed early growth and hepatic defects, including reduced liver weight, transient microvesicular fatty metamorphosis, prolonged extramedullary hematopoiesis, and portal hypercellularity with thickening and fibrosis.
AB - The Ah receptor (AHR) is a ligand-activated transcription factor that mediates a pleiotropic response to environmental contaminants such as benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. In an effort to gain insight into the physiological role of the AHR and to develop models useful in risk assessment, gene targeting was used to inactivate the murine Ahr gene by homologous recombination. Ahr(-/-) mice are viable and fertile but show a spectrum of hepatic defects thai indicate a role for the AHR in normal liver growth and development. The Ahr(-/-) phenotype is most severe between 0-3 weeks of age and involves slowed early growth and hepatic defects, including reduced liver weight, transient microvesicular fatty metamorphosis, prolonged extramedullary hematopoiesis, and portal hypercellularity with thickening and fibrosis.
KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin
KW - dioxin
KW - gene targeting
KW - liver
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U2 - 10.1073/pnas.93.13.6731
DO - 10.1073/pnas.93.13.6731
M3 - Article
C2 - 8692887
AN - SCOPUS:0030015421
SN - 0027-8424
VL - 93
SP - 6731
EP - 6736
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 13
ER -