Characterization of a retrovirus that cross-reacts serologically with canine and human systemic lupus erythematosus (SLE)

Fred W. Quimby*, Ronald Gebert, Syamal Datta, Janine André-Schwartz, Walter J. Tannenberg, Robert M. Lewis, I. Bernard Weinstein, Robert S. Schwartz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This report characterizes the SP104 virus, which was previously shown to contain an antigen that cross-reacts with an antigen present on surfaces of blood lymphocytes of human and canine patients with systemic lupus erythematosus (SLE). Morphologically, the virus was a Type C particle. By physicochemical characterization it was a typical retrovirus with a bouyant density of 1.15-1.17 g/cm3, high molecular weight RNA and RNA-dependent DNA polymerase. The virus had antigens that cross-reacted with p30, gp71, p12, and p15 of other murine retroviruses. Biologically, SP104 was characterized as a murine B-tropic virus that was only weakly oncogenic but highly efficient in eliciting the production of antinuclear antibody in mice. Nucleic acid hybridization experiments indicated that the RNA of SP104 virus had only partial identity with the other murine leukemia viruses tested. There was no evidence that the genetic sequences found in the SP104 virus were present in tissues from canine or human patients with SLE.

Original languageEnglish (US)
Pages (from-to)194-210
Number of pages17
JournalClinical Immunology and Immunopathology
Volume9
Issue number2
DOIs
StatePublished - Feb 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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