TY - JOUR
T1 - Characterization of a retrovirus that cross-reacts serologically with canine and human systemic lupus erythematosus (SLE)
AU - Quimby, Fred W.
AU - Gebert, Ronald
AU - Datta, Syamal
AU - André-Schwartz, Janine
AU - Tannenberg, Walter J.
AU - Lewis, Robert M.
AU - Weinstein, I. Bernard
AU - Schwartz, Robert S.
N1 - Funding Information:
I Supported by USPHS Grant Nos. AM 09351 and CA
PY - 1978/2
Y1 - 1978/2
N2 - This report characterizes the SP104 virus, which was previously shown to contain an antigen that cross-reacts with an antigen present on surfaces of blood lymphocytes of human and canine patients with systemic lupus erythematosus (SLE). Morphologically, the virus was a Type C particle. By physicochemical characterization it was a typical retrovirus with a bouyant density of 1.15-1.17 g/cm3, high molecular weight RNA and RNA-dependent DNA polymerase. The virus had antigens that cross-reacted with p30, gp71, p12, and p15 of other murine retroviruses. Biologically, SP104 was characterized as a murine B-tropic virus that was only weakly oncogenic but highly efficient in eliciting the production of antinuclear antibody in mice. Nucleic acid hybridization experiments indicated that the RNA of SP104 virus had only partial identity with the other murine leukemia viruses tested. There was no evidence that the genetic sequences found in the SP104 virus were present in tissues from canine or human patients with SLE.
AB - This report characterizes the SP104 virus, which was previously shown to contain an antigen that cross-reacts with an antigen present on surfaces of blood lymphocytes of human and canine patients with systemic lupus erythematosus (SLE). Morphologically, the virus was a Type C particle. By physicochemical characterization it was a typical retrovirus with a bouyant density of 1.15-1.17 g/cm3, high molecular weight RNA and RNA-dependent DNA polymerase. The virus had antigens that cross-reacted with p30, gp71, p12, and p15 of other murine retroviruses. Biologically, SP104 was characterized as a murine B-tropic virus that was only weakly oncogenic but highly efficient in eliciting the production of antinuclear antibody in mice. Nucleic acid hybridization experiments indicated that the RNA of SP104 virus had only partial identity with the other murine leukemia viruses tested. There was no evidence that the genetic sequences found in the SP104 virus were present in tissues from canine or human patients with SLE.
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U2 - 10.1016/0090-1229(78)90071-5
DO - 10.1016/0090-1229(78)90071-5
M3 - Article
C2 - 201411
AN - SCOPUS:0017810991
SN - 0090-1229
VL - 9
SP - 194
EP - 210
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -