Characterization of anomalous movements of spherical living cells on a silicon dioxide glassy substrate

Myeonggu Son, Gyudo Lee*, Jongsang Son, Seungyeop Choi, Youngho Kim, Sei Young Lee, Young Ro Yoon, Dae Sung Yoon, Sang Woo Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The random walk of spherical living cells on a silicon dioxide glassy substrate was studied experimentally and numerically. This random walk trajectory exhibited erratic dancing, which seemingly obeyed anomalous diffusion (i.e., Lévy-like walk) rather than normal diffusion. Moreover, the angular distribution (-π to π) of the cells' trajectory followed a "U-shaped pattern" in comparison to the uniform distribution seen in the movements of negatively charged polystyrene microspheres. These effects could be attributable to the homeostasis-driven structural resilient character of cells and physical interactions derived from temporarily retained nonspecific binding due to weak forces between the cells and substrates. Our results provide new insights into the stochastic behavior of mesoscopic biological particles with respect to structural properties and physical interactions.

Original languageEnglish (US)
Article number014102
JournalBiomicrofluidics
Volume9
Issue number1
DOIs
StatePublished - Jan 7 2015

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes
  • Colloid and Surface Chemistry

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