Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

Richard D. Schaller*, Justin C. Johnson, Kevin R. Wilson, Lynn F. Lee, Louis H. Haber, Richard J. Saykally

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2002
EventCommercial and Biomedical Applications of Ultrafast and Free-Electron Lasers - San Jose, CA, United States
Duration: Jan 23 2002Jan 24 2002

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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