Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

Richard D. Schaller; Justin C. Johnson; Kevin R. Wilson; Lynn F. Lee; Louis H. Haber; Richard J. Saykally

doi:10.1117/12.461388

Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

Richard D. Schaller^*, Justin C. Johnson, Kevin R. Wilson, Lynn F. Lee, Louis H. Haber, Richard J. Saykally

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Conference article › peer-review

Abstract

Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

Original language	English (US)
Pages (from-to)	62-68
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4633
DOIs	https://doi.org/10.1117/12.461388
State	Published - 2002
Event	Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers - San Jose, CA, United States Duration: Jan 23 2002 → Jan 24 2002

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.461388

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title = "Characterization of biological structures with nonlinear chemical imaging nanomicroscopy",

abstract = "Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.",

author = "Schaller, {Richard D.} and Johnson, {Justin C.} and Wilson, {Kevin R.} and Lee, {Lynn F.} and Haber, {Louis H.} and Saykally, {Richard J.}",

year = "2002",

doi = "10.1117/12.461388",

language = "English (US)",

volume = "4633",

pages = "62--68",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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note = "Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers ; Conference date: 23-01-2002 Through 24-01-2002",

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T1 - Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

AU - Schaller, Richard D.

AU - Johnson, Justin C.

AU - Wilson, Kevin R.

AU - Lee, Lynn F.

AU - Haber, Louis H.

AU - Saykally, Richard J.

PY - 2002

Y1 - 2002

N2 - Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

AB - Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

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DO - 10.1117/12.461388

M3 - Conference article

AN - SCOPUS:0036403510

SN - 0277-786X

VL - 4633

SP - 62

EP - 68

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers

Y2 - 23 January 2002 through 24 January 2002

ER -

Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

Abstract

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