Characterization of frequently sampled intravenous glucose tolerance test using scaling and sensitivity analysis of MINMOD

K. Lakshmi Kiran, Manoj Kandpal, S. Lakshminarayanan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Model reduction is an important step in modeling before the model can be deployed for practical applications. Its application to complex biological systems is often very useful. In this work, a minimal model expounding the glucose insulin interactions is considered and scaling analysis is applied to reduce the number of parameters and scale them to ∼O(1). FSIVGTT is one of the diagnostic procedures to check the diabetic condition of an individual. Here, in silico studies are done to characterize the sampling times of existing FSIVGTT. In this regard, global sensitivity analysis is performed on the reduced parametric model to unravel the key parameters influencing the glucose and insulin concentration at the sampling times of FSIVGTT. Overall, this analysis can be beneficial to medical community in designing experiments for implementing novel and efficient diagnostic protocols.

Original languageEnglish (US)
Title of host publication2010 International Conference on Modelling, Identification and Control, ICMIC 2010
Pages179-184
Number of pages6
StatePublished - Oct 18 2010
Event2010 International Conference on Modelling, Identification and Control, ICMIC 2010 - Okayama, Japan
Duration: Jul 17 2010Jul 19 2010

Other

Other2010 International Conference on Modelling, Identification and Control, ICMIC 2010
CountryJapan
CityOkayama
Period7/17/107/19/10

ASJC Scopus subject areas

  • Control and Systems Engineering

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