Characterization of lymphocyte subpopulations in Warthin’s tumor

Kenley W. Chin, Kathleen R Billings, Akira Ishiyama, Marilene B. Wang, Phillip A. Wackym*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cell suspensions from six Warthin’s tumors (Wis) were characterized with fluorescence-labeled cell cytometry. WT lymphocyte subsets were identified with monoclonal antibodies directed against lymphocyte-associated cell antigens including T lymphocyte subsets, B lymphocytes, and natural killer (NK) cells. Results showed that T cell proportions were 58% and B cell proportions were 39%. The T cell helper:cytotox-ic-suppressor ratio was 5.7:1 and the B to T cell ratio was 0.8:1. NK cells represented 1.3% of cells. When compared to peripheral blood lymphocytes (PBLs) in the same patients, statistically significant differences were noted between PBLs and WT lymphocytes in the percentage of B lymphocytes (P<.01), T cytotoxic-sup-pressor lymphocytes (P<.02), NK cells (P<.01), and in the ratios of B to T lymphocytes (P<.01) and T helper to T cytotoxic-suppressor lymphocytes (P<.03). Comparing these data to retrospective data on lymphocyte distribution in normal and reactive lymph nodes, the epithelial component does not appear to exert a local effect on the lymphoid component of WT.

Original languageEnglish (US)
Pages (from-to)928-933
Number of pages6
JournalLaryngoscope
Volume105
Issue number9
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Otorhinolaryngology

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