Characterization of single auditory nerve fibers in response to laser stimulation

Phillip Littlefield, Agnella D. Izzo, Jagmeet Mundi, Joseph T. Walsh, E. Duco Jansen, Mark Bendett, Jim Webb, Heather Ralph, Claus Peter Richter*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

One drawback with traditional cochlear implants, which use electrical currents to stimulate spiral ganglion cells, is the ability to stimulate spatially discrete cells without overlap and electric current spread. We have recently demonstrated that spatially selective stimulation of the cochlea is possible with optical stimulation. However, for light to be a useful stimulation paradigm for stimulation of neurons, including cochlear implants, the neurons must be stimulated at high stimulus repetition rates. In this paper we utilize single fiber recordings from the auditory nerve to demonstrate that stimulation is possible at high repetition rates of the light pulses. Results showed that action potentials occurred 2.5-4. ms after the laser pulse. Maximum rates of discharge were up to 300 Hz. The action potentials did not respond strictly after the light pulse with high stimulation rates, i.e. >300 pulses per second. The correlation between the action potentials and the laser pulses decreased drastically for laser pulse repetition rate larger than 300 pulses per second.

Original languageEnglish (US)
Title of host publicationOptical Interactions with Tissue and Cells XIX
DOIs
StatePublished - Apr 21 2008
EventOptical Interactions with Tissue and Cells XIX - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6854
ISSN (Print)1605-7422

Other

OtherOptical Interactions with Tissue and Cells XIX
CountryUnited States
CitySan Jose, CA
Period1/21/081/23/08

Keywords

  • Cochlear implantation
  • High repetition rates
  • Optical stimulation
  • Single fiber

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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