Characterization of the defective autologous mixed lymphocyte response in rheumatoid arthritis

Richard M. Pope*, Linda Mcchesney, Norman Talal, Michael Fischbach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

In order to characterize the autologous mixed lymphocyte response (AMLR) in patients with rheumatoid arthritis (RA) and to define the relationship with disease activity, peripheral blood T lymphocytes were stimulated with either a B lymphocyte‐enriched (B cells) or a macrophage‐enriched (macrophages) population. A significant reduction (P < 0.01 to P < 0.001) of T cell proliferation stimulated both by B cells and macrophages was observed in patients with active disease. The B lymphocytes were significantly less stimulatory (P < 0.02 to P < 0.001) than macrophages in the patients compared with the controls. In the normal controls, macrophages in higher concentrations were capable of suppressing the B lymphocyte‐stimulated AMLR, but macrophages from patients with RA were not excessively suppressive. A significant association (P < 0.02) was observed between disease activity and the AMLR. Using the B‐enriched population, the AMLR proliferative response was significantly associated (P < 0.001) with the production of interleukin‐2. Defects in proliferation could only be partially restored by the addition of interleukin‐2. These data indicate that the defective AMLR observed in patients with RA is related to disease activity and is associated with altered cellular interactions among T lymphocytes, macrophages, and the B lymphocyte‐enriched population.

Original languageEnglish (US)
Pages (from-to)1234-1244
Number of pages11
JournalArthritis & Rheumatism
Volume27
Issue number11
DOIs
StatePublished - Nov 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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