Abstract
The MCT-1 oncogene was initially identified as an amplified gene on chromosome Xq22-24 in a T-cell lymphoma. MCT-1 is over-expressed in a subset of diffuse large B-cell lymphoma (DLBCL), a common form of Non-Hodgkin's Lymphoma (NHL). We have identified a pseudogene for MCT-1 (ΨMCT-1) that is located on chromosome 20q11.2, a region within an amplicon containing several important genes frequently amplified in certain breast and ovarian cancers. Genomic analysis revealed that ΨMCT-1 is a processed pseudogene. Interestingly, both MCT-1 and its pseudogene are located on regions of the genome that are frequently amplified in several different human malignancies. MCT-1 is the oldest known oncogene and its insertion as a pseudogene occurred at a later time point in evolution. Existence of ΨMCT-1 should be considered when analyzing genomic amplification and or expression of MCT-1. Analysis of MCT-1 and ΨMCT-1 might provide clues to cancer genes and their evolution across species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 234-239 |
| Number of pages | 6 |
| Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
| Volume | 1759 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2006 |
Keywords
- Gene amplification
- Lymphoma
- MCT-1 oncogene
- Pseudogene
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Genetics
