Characterization of the MCT-1 pseudogene: Identification and implication of its location in a highly amplified region of chromosome 20

Suvobroto Nandi*, Bo Shi, Jonathan Perreault, Ronald B. Gartenhaus

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The MCT-1 oncogene was initially identified as an amplified gene on chromosome Xq22-24 in a T-cell lymphoma. MCT-1 is over-expressed in a subset of diffuse large B-cell lymphoma (DLBCL), a common form of Non-Hodgkin's Lymphoma (NHL). We have identified a pseudogene for MCT-1 (ΨMCT-1) that is located on chromosome 20q11.2, a region within an amplicon containing several important genes frequently amplified in certain breast and ovarian cancers. Genomic analysis revealed that ΨMCT-1 is a processed pseudogene. Interestingly, both MCT-1 and its pseudogene are located on regions of the genome that are frequently amplified in several different human malignancies. MCT-1 is the oldest known oncogene and its insertion as a pseudogene occurred at a later time point in evolution. Existence of ΨMCT-1 should be considered when analyzing genomic amplification and or expression of MCT-1. Analysis of MCT-1 and ΨMCT-1 might provide clues to cancer genes and their evolution across species.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1759
Issue number5
DOIs
StatePublished - May 1 2006

Keywords

  • Gene amplification
  • Lymphoma
  • MCT-1 oncogene
  • Pseudogene

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Characterization of the MCT-1 pseudogene: Identification and implication of its location in a highly amplified region of chromosome 20'. Together they form a unique fingerprint.

  • Cite this