Characterization of the molecular weights of bovine molar, rat incisor, and other phosphophoryns

Mohammed M. Rahima*, Boris Sabsay, Chou Bing Wu, Arthur Veis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The phosphophoryns show anomalous behavior in solution, and are easily degraded during extraction. They appear in varied forms in the teeth of different species and differ in the teeth of the same species in a developmental and age dependent fashion. This set of properties has made the characterization of the phosphophoryns by biochemical means a difficult and controversial subject. Bovine molar phosphophoryn, bPP, has been characterized in detail by a variety of physical methods, and then compared with the PP from other species by DEAE-HPLC, gel electrophoresis, and immunological cross reactivity. The possible existence of a proPP biosynthetic precursor has been investigated by rat incisor organ culture and examination of the 32P and 14C labeled products. These studies all show marked differences in the Mr values for the PP from teeth of different species, even when they are antigenically cross-reactive.

Original languageEnglish (US)
Pages (from-to)705-716
Number of pages12
JournalConnective tissue research
Issue number1-4
StatePublished - 1989


  • Biosynthesis
  • Gel electrophoresis
  • Molecular weights
  • Phosphophoryns
  • Post-translational processing
  • Ultracentrifugation
  • Viscosity

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Rheumatology
  • Cell Biology
  • Orthopedics and Sports Medicine


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