Characterization of the regulatory region of the Escherichia coli penicillin acylase structural gene

F. Valle, G. Gosset, B. Tenorio, G. Oliver, F. Bolivar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Penicillin acylase is utilized in the enzymatic production of semisynthetic penicillins. The enzyme is composed of two different subunits that originate from a common precursor. The partial nucleotide (nt) sequence of the structural gene has been published. This paper reports the nt sequence of the regulatory region of this gene, the identification of a functional promoter, the transcriptional start point, and the description of possible regulatory regions.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalGene
Volume50
Issue number1-3
DOIs
StatePublished - 1986

Keywords

  • Nucleotide sequence
  • primer extension
  • promoter identification

ASJC Scopus subject areas

  • Genetics

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