Characterization of the zebrafish tbx16 gene and evolution of the vertebrate T-box family

Ilya Ruvinsky, Lee M. Silver, Robert K. Ho*

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

We report on a new zebrafish T-box-containing gene, tbx16. It encodes a message that is first detected throughout the blastoderm soon after the initiation of zygotic gene expression. Following gastrulation, expression becomes restricted to paraxial mesoderm and later primarily to the developing tail bud. To gain an evolutionary prospective on the potential function of this gene, we have analyzed its phylogenetic relationships to known T-box genes from other species. Zebrafish tbx16 is likely orthologous to the chicken Tbx6L and Xenopus Xombi/Antipodean/Brat/VegT genes. Our analysis also shows that zebrafish tbx6 and mouse Tbx6 genes are paralogous to zebrafish tbx16. We present evidence which argues, that despite the same name and similar expression, zebrafish tbx6 and mouse Tbx6 genes are not orthologous to each other but instead represent relatively distant paralogs. The expression patterns of all genes are discussed in the light of their evolutionary relationships.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
JournalDevelopment Genes and Evolution
Volume208
Issue number2
DOIs
StatePublished - Jun 2 1998

Keywords

  • Evolution
  • Paraxial mesoderm
  • T-box
  • Tail bud
  • Zebrafish

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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