Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system

Aurelien Descazeaud, Alexandre De La Taille, Yves Allory, Hugo Faucon, Laurent Salomon, Tarek Bismar, Robert Kim, Matthias D. Hofer, Dominique Chopin, Claude C. Abbou, Mark A. Rubin*

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

OBJECTIVE. Zinc-alpha-2-glycoprotein 1 (ZAG) is a 41-kD secreted protein that is known to stimulate lipid degradation in adipocytes. The aim of this study was to determine how ZAC protein expression is associated with prostate cancer (PCa). MATERIALS AND METHODS. An immunohistochemistry analysis was performed on a 227 PCa tissue microarray cases. ZAG protein expression was assessed using a semi-automated cellular image analysis system. RESULTS. ZAG expression was associated with tumor stage (pT2 > pT3 > metastasis cases, P < 0.001), and was inversely associated with Gleason score on pathology (P = 001). ZAG intensity was predictive of biochemical recurrence (P = 0.002). On multivariate analysis including pT2 patients, the predictive factors of biochemical recurrence were ZAG expression (P = 0.016), Gleason score (P = 0.011), and surgical margin status (P = 0.047). CONCLUSIONS. This study characterized ZAG protein expression in PCa using a semi-automated system. ZAG expression level found to have an independent prognostic value for pT2 patients.

Original languageEnglish (US)
Pages (from-to)1037-1043
Number of pages7
JournalProstate
Volume66
Issue number10
DOIs
StatePublished - Jul 1 2006

Keywords

  • AZGP1
  • Prostate
  • Prostate carcinoma
  • Protein expression
  • Tissue microarrays
  • ZAG

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Descazeaud, A., De La Taille, A., Allory, Y., Faucon, H., Salomon, L., Bismar, T., Kim, R., Hofer, M. D., Chopin, D., Abbou, C. C., & Rubin, M. A. (2006). Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system. Prostate, 66(10), 1037-1043. https://doi.org/10.1002/pros.20405