Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system

Aurelien Descazeaud; Alexandre De La Taille; Yves Allory; Hugo Faucon; Laurent Salomon; Tarek Bismar; Robert Kim; Matthias D. Hofer; Dominique Chopin; Claude C. Abbou; Mark A. Rubin

doi:10.1002/pros.20405

Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system

Aurelien Descazeaud, Alexandre De La Taille, Yves Allory, Hugo Faucon, Laurent Salomon, Tarek Bismar, Robert Kim, Matthias D. Hofer, Dominique Chopin, Claude C. Abbou, Mark A. Rubin^*

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

OBJECTIVE. Zinc-alpha-2-glycoprotein 1 (ZAG) is a 41-kD secreted protein that is known to stimulate lipid degradation in adipocytes. The aim of this study was to determine how ZAC protein expression is associated with prostate cancer (PCa). MATERIALS AND METHODS. An immunohistochemistry analysis was performed on a 227 PCa tissue microarray cases. ZAG protein expression was assessed using a semi-automated cellular image analysis system. RESULTS. ZAG expression was associated with tumor stage (pT2 > pT3 > metastasis cases, P < 0.001), and was inversely associated with Gleason score on pathology (P = 001). ZAG intensity was predictive of biochemical recurrence (P = 0.002). On multivariate analysis including pT2 patients, the predictive factors of biochemical recurrence were ZAG expression (P = 0.016), Gleason score (P = 0.011), and surgical margin status (P = 0.047). CONCLUSIONS. This study characterized ZAG protein expression in PCa using a semi-automated system. ZAG expression level found to have an independent prognostic value for pT2 patients.

Original language	English (US)
Pages (from-to)	1037-1043
Number of pages	7
Journal	Prostate
Volume	66
Issue number	10
DOIs	https://doi.org/10.1002/pros.20405
State	Published - Jul 1 2006

Keywords

AZGP1
Prostate
Prostate carcinoma
Protein expression
Tissue microarrays
ZAG

ASJC Scopus subject areas

Urology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/pros.20405

Cite this

@article{b18c9f4974d843368605351b7c722da5,

title = "Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system",

abstract = "OBJECTIVE. Zinc-alpha-2-glycoprotein 1 (ZAG) is a 41-kD secreted protein that is known to stimulate lipid degradation in adipocytes. The aim of this study was to determine how ZAC protein expression is associated with prostate cancer (PCa). MATERIALS AND METHODS. An immunohistochemistry analysis was performed on a 227 PCa tissue microarray cases. ZAG protein expression was assessed using a semi-automated cellular image analysis system. RESULTS. ZAG expression was associated with tumor stage (pT2 > pT3 > metastasis cases, P < 0.001), and was inversely associated with Gleason score on pathology (P = 001). ZAG intensity was predictive of biochemical recurrence (P = 0.002). On multivariate analysis including pT2 patients, the predictive factors of biochemical recurrence were ZAG expression (P = 0.016), Gleason score (P = 0.011), and surgical margin status (P = 0.047). CONCLUSIONS. This study characterized ZAG protein expression in PCa using a semi-automated system. ZAG expression level found to have an independent prognostic value for pT2 patients.",

keywords = "AZGP1, Prostate, Prostate carcinoma, Protein expression, Tissue microarrays, ZAG",

author = "Aurelien Descazeaud and {De La Taille}, Alexandre and Yves Allory and Hugo Faucon and Laurent Salomon and Tarek Bismar and Robert Kim and Hofer, {Matthias D.} and Dominique Chopin and Abbou, {Claude C.} and Rubin, {Mark A.}",

year = "2006",

month = jul,

day = "1",

doi = "10.1002/pros.20405",

language = "English (US)",

volume = "66",

pages = "1037--1043",

journal = "Prostate",

issn = "0270-4137",

publisher = "Wiley-Liss Inc.",

number = "10",

}

TY - JOUR

T1 - Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system

AU - Descazeaud, Aurelien

AU - De La Taille, Alexandre

AU - Allory, Yves

AU - Faucon, Hugo

AU - Salomon, Laurent

AU - Bismar, Tarek

AU - Kim, Robert

AU - Hofer, Matthias D.

AU - Chopin, Dominique

AU - Abbou, Claude C.

AU - Rubin, Mark A.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - OBJECTIVE. Zinc-alpha-2-glycoprotein 1 (ZAG) is a 41-kD secreted protein that is known to stimulate lipid degradation in adipocytes. The aim of this study was to determine how ZAC protein expression is associated with prostate cancer (PCa). MATERIALS AND METHODS. An immunohistochemistry analysis was performed on a 227 PCa tissue microarray cases. ZAG protein expression was assessed using a semi-automated cellular image analysis system. RESULTS. ZAG expression was associated with tumor stage (pT2 > pT3 > metastasis cases, P < 0.001), and was inversely associated with Gleason score on pathology (P = 001). ZAG intensity was predictive of biochemical recurrence (P = 0.002). On multivariate analysis including pT2 patients, the predictive factors of biochemical recurrence were ZAG expression (P = 0.016), Gleason score (P = 0.011), and surgical margin status (P = 0.047). CONCLUSIONS. This study characterized ZAG protein expression in PCa using a semi-automated system. ZAG expression level found to have an independent prognostic value for pT2 patients.

AB - OBJECTIVE. Zinc-alpha-2-glycoprotein 1 (ZAG) is a 41-kD secreted protein that is known to stimulate lipid degradation in adipocytes. The aim of this study was to determine how ZAC protein expression is associated with prostate cancer (PCa). MATERIALS AND METHODS. An immunohistochemistry analysis was performed on a 227 PCa tissue microarray cases. ZAG protein expression was assessed using a semi-automated cellular image analysis system. RESULTS. ZAG expression was associated with tumor stage (pT2 > pT3 > metastasis cases, P < 0.001), and was inversely associated with Gleason score on pathology (P = 001). ZAG intensity was predictive of biochemical recurrence (P = 0.002). On multivariate analysis including pT2 patients, the predictive factors of biochemical recurrence were ZAG expression (P = 0.016), Gleason score (P = 0.011), and surgical margin status (P = 0.047). CONCLUSIONS. This study characterized ZAG protein expression in PCa using a semi-automated system. ZAG expression level found to have an independent prognostic value for pT2 patients.

KW - AZGP1

KW - Prostate

KW - Prostate carcinoma

KW - Protein expression

KW - Tissue microarrays

KW - ZAG

UR - http://www.scopus.com/inward/record.url?scp=33745295638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745295638&partnerID=8YFLogxK

U2 - 10.1002/pros.20405

DO - 10.1002/pros.20405

M3 - Article

C2 - 16598739

AN - SCOPUS:33745295638

SN - 0270-4137

VL - 66

SP - 1037

EP - 1043

JO - Prostate

JF - Prostate

IS - 10

ER -

Characterization of ZAG protein expression in prostate cancer using a semi-automated microscope system

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this