Characterizing Cognitive Impairment in Parkinson's Disease

Meagan Bailey*, Jennifer G Goldman

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cognitive impairment is a frequent complication in Parkinson's disease (PD), though it can be heterogeneous in its presentation and progression. Cognitive deficits vary among patients with regard to clinical features, severity, and progression to dementia. A growing recognition of cognitive impairment in PD in both the clinical and research settings has led to advances in diagnostic criteria and improved understanding of the clinical phenotypes, associated biomarkers, and underlying pathophysiology of both PD dementia and PD mild cognitive impairment. Therapeutic interventions are geared to improve symptoms and ideally to prevent cognitive decline. Here the authors summarize the current research on the characterization of cognitive impairment in PD, with specific attention focused on its clinical phenotype, associated neuropsychiatric and prodromal features, pathological changes, genetic variations, and imaging and biochemical biomarkers.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalSeminars in Neurology
Volume37
Issue number2
DOIs
StatePublished - Apr 1 2017

Keywords

  • Parkinson's disease
  • biomarkers
  • dementia
  • mild cognitive impairment
  • pathology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Characterizing Cognitive Impairment in Parkinson's Disease'. Together they form a unique fingerprint.

  • Cite this