Characterizing dispersion in microfluidic channels

Subhra Datta*, Sandip Ghosal

*Corresponding author for this work

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Dispersion or spreading of analyte bands is a barrier to achieving high resolution in microfluidic separations. The role of dispersion in separations is reviewed with emphasis on metrics, sources and common principles of analysis. Three sources of dispersion (a) inhomogeneous flow fields, (b) solute wall interactions and (c) force fields normal to channel walls are studied in detail. Microfluidic and nanofluidic applications to capillary electrophoresis, chromatography and field-flow fractionation, that are subject to one or more of these three physical processes under standard, unintentional or novel operating conditions, are discussed.

Original languageEnglish (US)
Pages (from-to)2537-2550
Number of pages14
JournalLab on a Chip
Volume9
Issue number17
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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