Chemical and photochemical ligation of oligonucleotide blocks

Robert L. Letsinger*, Taifeng Wu, Robert Elghanian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide contaning a -OP(O)(O')S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.

Original languageEnglish (US)
Pages (from-to)643-652
Number of pages10
JournalNucleosides and Nucleotides
Issue number5-6
StatePublished - 1997

ASJC Scopus subject areas

  • Biochemistry
  • Genetics


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