Chemical and photochemical ligation of oligonucleotide blocks

Robert L. Letsinger; Taifeng Wu; Robert Elghanian

doi:10.1080/07328319708002929

Chemical and photochemical ligation of oligonucleotide blocks

Robert L. Letsinger^*, Taifeng Wu, Robert Elghanian

^*Corresponding author for this work

Robert H. Lurie Comprehensive Cancer Center

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide contaning a -OP(O)(O')S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.

Original language	English (US)
Pages (from-to)	643-652
Number of pages	10
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	5-6
DOIs	https://doi.org/10.1080/07328319708002929
State	Published - 1997

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319708002929

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title = "Chemical and photochemical ligation of oligonucleotide blocks",

abstract = "Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide contaning a -OP(O)(O')S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.",

author = "Letsinger, {Robert L.} and Taifeng Wu and Robert Elghanian",

note = "Funding Information: Acknowledgement. This research was supported by the National Institute of General",

year = "1997",

doi = "10.1080/07328319708002929",

language = "English (US)",

volume = "16",

pages = "643--652",

journal = "Nucleosides and Nucleotides",

issn = "0732-8311",

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TY - JOUR

T1 - Chemical and photochemical ligation of oligonucleotide blocks

AU - Letsinger, Robert L.

AU - Wu, Taifeng

AU - Elghanian, Robert

N1 - Funding Information: Acknowledgement. This research was supported by the National Institute of General

PY - 1997

Y1 - 1997

N2 - Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide contaning a -OP(O)(O')S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.

AB - Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide contaning a -OP(O)(O')S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.

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U2 - 10.1080/07328319708002929

DO - 10.1080/07328319708002929

M3 - Article

AN - SCOPUS:0030755650

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EP - 652

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 5-6

ER -

Chemical and photochemical ligation of oligonucleotide blocks

Abstract

ASJC Scopus subject areas

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