Abstract
Several efficient means for joining oligonucleotides in dilute solution by non-natural internucleotide bridges are discussed. It is also shown that an oligonucleotide contaning a -OP(O)(O')S- link can function as an effective template in PCR amplification and that oligonucleotide probes containing stilbenedicarboxamide groups can serve in monitoring the presence of mismatched bases in an oligonucleotide target.
Original language | English (US) |
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Pages (from-to) | 643-652 |
Number of pages | 10 |
Journal | Nucleosides and Nucleotides |
Volume | 16 |
Issue number | 5-6 |
DOIs | |
State | Published - 1997 |
ASJC Scopus subject areas
- Biochemistry
- Genetics