Chemical Carcinogens Without Mutagenic Activity: Peroxisome Proliferators As A Prototype

Janardan K. Reddy, Dante G. Scarpelli, Vadrevu Subbarao, Narendra D. Lalwani

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Chemical carcinogens can be classified into two categories (i.e. mutagenic and non-mutagenic) on the basis of positive or negative evidence of DNA damage, mutagenicity or chromosomal aberrations in short-term test systems. Evidence indicates that carcinogenic peroxisome proliferators are negative in short-term test systems. This paper outlines approaches which may be useful in identifying a chemical carcinogen without mutagenic activity. It is conceivable that an alteration in DNA, if essential for initiation of neoplasia, may be mediated indirectly by the biological effects of nonmutagenic carcinogens.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalToxicologic Pathology
Volume11
Issue number2
DOIs
StatePublished - Feb 1983

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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