Chemistry of oligonucleotide-gold nanoparticle conjugates

Robert L. Letsinger*, Chad A. Mirkin, Robert Elghanian, Robert C. Mucic, James J. Storhoff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Conjugates prepared by immobilizing thiol-terminated oligonucleotides onto gold nanoparticles form stable colloidal solutions in aqueous media. The oligonucleotides can serve as linkers to organize the gold particles reversibly into three dimensional assemblies, and the gold particles can function as colorimetric reporters for hybridization of the bound oligomers with target oligonucleotides in solution.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalPhosphorus, Sulfur and Silicon and Related Elements
StatePublished - 1999


  • Gold
  • Hybridization
  • Nanoparticles
  • Non-radioactive detection
  • Oligonucleotide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry


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