Chemokine receptors and neural function

Charlene Cho, Richard J. Miller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Numerous studies have demonstrated that chemokines play an integral role in diseases marked by inflammation. Recently, it has also been shown that chemokines and their receptors are widely expressed in the central nervous system by all types of cells, including neurons. The functions of neuronal chemokine receptors have yet to be fully defined. However, there are indications that neuronal chemokine receptors play an integral role in the development of the nervous system, in the regulation of neuronal excitability and in the signal transduction pathways that regulate neuronal survival. This review explores these topics and discusses the overall impact that chemokines may have on neuronal function.

Original languageEnglish (US)
Pages (from-to)573-584
Number of pages12
JournalJournal of neurovirology
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2002

Keywords

  • Calcium
  • GPCR
  • Neuronal survival
  • Neurotransmission
  • Signal transduction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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