TY - JOUR
T1 - Chemokines in tumor progression and metastasis
AU - Sarvaiya, Purvaba J.
AU - Guo, Donna
AU - Ulasov, Ilya
AU - Gabikian, Patrik
AU - Lesniak, Maciej S.
PY - 2013/12
Y1 - 2013/12
N2 - Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, melanoma, lung cancer, gastric cancer, acute lymphoblastic leukemia, colon cancer, non-small lung cancer and non-hodgkin's lymphoma among many others. The expression of chemokines and their receptors is altered in many malignancies and leads to aberrant chemokine receptor signaling. This review focuses on the role of chemokines in key processes that facilitate tumor progression including proliferation, senescence, angiogenesis, epithelial mesenchymal transition, immune evasion and metastasis.
AB - Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, melanoma, lung cancer, gastric cancer, acute lymphoblastic leukemia, colon cancer, non-small lung cancer and non-hodgkin's lymphoma among many others. The expression of chemokines and their receptors is altered in many malignancies and leads to aberrant chemokine receptor signaling. This review focuses on the role of chemokines in key processes that facilitate tumor progression including proliferation, senescence, angiogenesis, epithelial mesenchymal transition, immune evasion and metastasis.
KW - Cancer
KW - Chemokine receptors
KW - Chemokines
KW - Metastasis
UR - http://www.scopus.com/inward/record.url?scp=84891960758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891960758&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.1426
DO - 10.18632/oncotarget.1426
M3 - Article
C2 - 24259307
AN - SCOPUS:84891960758
VL - 4
SP - 2171
EP - 2185
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 12
ER -
