Chemoprevention of chronic inflammatory bowel disease-induced carcinogenesis in rodent models by berries

Allison Yang, Haonan Li, Wanying Zhang, Yeon Tae Chung, Jie Liao, Guang-Yu Yang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Long-term chronic inflammation including inflammatory bowel disease is a well-recognized risk factor for cancer development. Fresh fruits, particularly berries, have been well documented as having protective effects against inflammation and cancer development. There are several key elements in the berries with functions against cancer, including vitamins (A, C, E, and folic acid), minerals (calcium and selenium), phenol compounds (particularly ellagic acid, ferulic acid, chlorogenic acid, coumaric acid, quercetin and anthocyanins), phytosterols (β-sitosterol, campesterol, and stigmasterol) and oligosaccharides. This chapter focuses on linking berries to chronic colitis-induced carcinogenesis from experimental evidence to potential usefulness on cancer prevention and treatment.

Original languageEnglish (US)
Title of host publicationBerries and Cancer Prevention
PublisherSpringer New York
Pages227-243
Number of pages17
ISBN (Print)9781441975539
DOIs
StatePublished - Dec 1 2011

Keywords

  • Animal model
  • Anthocyanins
  • Berry
  • Cancer
  • Carcinogenesis
  • Chemoprevention
  • Crohn's disease
  • Fiber
  • Fruit
  • Inflammation
  • Inflammatory bowel disease
  • Oligosaccharides
  • Oxidative stress
  • Oxylipin
  • Phytosterols
  • Ulcerative colitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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