Chemotherapy in the treatment of malignant gliomas

Jennifer I. Stern, Jeffrey J. Raizer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Malignant gliomas are one of the most difficult tumors to treat, with only modest advances being made in the past few decades. Surgery and radiation have had the greatest impact, increasing survival. Chemotherapy modestly increases survival. The use of chemotherapy in the treatment of malignant gliomas is the focus of this paper and the more commonly used agents at diagnosis and relapse are reviewed. Since most patients fail first-, second-and even third-line agents that are commercially available, some of the more relevant new biological compounds will also be discussed. As treatments for brain tumors evolve, it is likely that optimal therapies will come from combination therapies that incorporate target-specific and chemotherapeutic agents.

Original languageEnglish (US)
Pages (from-to)755-767
Number of pages13
JournalExpert review of anticancer therapy
Issue number5
StatePublished - May 1 2006


  • Anaplastic astrocytoma
  • Chemotherapy
  • Glioblastoma
  • Malignant glioma
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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