Chemotherapy: What is its role in meningioma?

W. J. Sherman; J. J. Raizer

doi:10.1586/ern.12.108

Chemotherapy: What is its role in meningioma?

W. J. Sherman, J. J. Raizer^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

While strong evidence exists for the standard therapy for meningiomas, inclusive of surgery and/or radiation therapy, for those tumors which recur, progress or are inoperable, the optimal medical therapies are yet to be elucidated. This article reviews the current literature for chemotherapeutic options for this subset of tumors, including cytotoxic agents, biologic agents, targeted molecular agents and hormonal agents. At this point in time, the most data is with hydroxyurea and somatostatin, although further trials with combination and targeted molecular therapies are still underway.

Original language	English (US)
Pages (from-to)	1189-1196
Number of pages	8
Journal	Expert Review of Neurotherapeutics
Volume	12
Issue number	10
DOIs	https://doi.org/10.1586/ern.12.108
State	Published - Oct 2012

Keywords

IFN-a
bevacizumab
chemotherapy
erlotinib
gefitinib
hydroxyurea
imatinib mesylate
meningioma
mifepristone
octreotide
somatostatin
tamoxifen

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology
Pharmacology (medical)

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10.1586/ern.12.108

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title = "Chemotherapy: What is its role in meningioma?",

abstract = "While strong evidence exists for the standard therapy for meningiomas, inclusive of surgery and/or radiation therapy, for those tumors which recur, progress or are inoperable, the optimal medical therapies are yet to be elucidated. This article reviews the current literature for chemotherapeutic options for this subset of tumors, including cytotoxic agents, biologic agents, targeted molecular agents and hormonal agents. At this point in time, the most data is with hydroxyurea and somatostatin, although further trials with combination and targeted molecular therapies are still underway.",

keywords = "IFN-a, bevacizumab, chemotherapy, erlotinib, gefitinib, hydroxyurea, imatinib mesylate, meningioma, mifepristone, octreotide, somatostatin, tamoxifen",

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KW - IFN-a

KW - bevacizumab

KW - chemotherapy

KW - erlotinib

KW - gefitinib

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KW - imatinib mesylate

KW - meningioma

KW - mifepristone

KW - octreotide

KW - somatostatin

KW - tamoxifen

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Chemotherapy: What is its role in meningioma?

Abstract

Keywords

ASJC Scopus subject areas

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