Chicago Classification of esophageal motility disorders: Past, present, and future

Kelli DeLay*, Rena Yadlapati, John E. Pandolfino

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The Chicago Classification (CC) is a dynamic, evolving classification scheme created by a diverse group of international esophageal experts. Its application has transformed the way esophageal motor data are used to define motility disorders, each iteration seeking to advance, simplify, and standardize the way clinicians worldwide diagnose esophageal dysmotility. The most recent update, CC version 4.0 (CCv4.0), emphasizes the importance of clinical context and distinguishes clinically relevant, conclusive manometric diagnoses from irrelevant manometric observations. Future iterations of CC may refine the classification of spastic esophageal disorders and incorporate machine learning and physics-based modeling to improve metrics.

Original languageEnglish (US)
Pages (from-to)120-130
Number of pages11
JournalIndian Journal of Gastroenterology
Issue number2
StatePublished - Apr 2021


  • Esophageal motility disorders
  • Esophageal pressure topography
  • High-resolution esophageal manometry

ASJC Scopus subject areas

  • Gastroenterology


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