Chicago healthy aging study: Objectives and design

Amber Pirzada*, Kathryn Reid, Daniel Kim, Daniel B. Garside, Brandon Lu, Thanh Huyen T. Vu, Donald M. Lloyd-Jones, Phyllis Zee, Kiang Liu, Jeremiah Stamler, Martha L. Daviglus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Investigators in the Chicago Healthy Aging Study (CHAS) reexamined 1,395 surviving participants aged 65-84 years (28% women) from the Chicago Heart Association Detection Project in Industry (CHA) 1967-1973 cohort whose cardiovascular disease (CVD) risk profiles were originally ascertained at ages 25-44 years. CHAS investigators reexamined 421 participants who were low-risk (LR) at baseline and 974 participants who were non-LR at baseline. LR was defined as having favorable levels of 4 major CVD risk factors: serum total cholesterol level <200 mg/dL and no use of cholesterol-lowering medication; blood pressure 120/≤80 mm Hg and no use of antihypertensive medication; no current smoking; and no history of diabetes or heart attack. While the potential of LR status in overcoming the CVD epidemic is being recognized, the long-term association of LR with objectively measured health in older age has not been examined. It is hypothesized that persons who were LR in 1967-1973 and have survived to older age will have less clinical and subclinical CVD, lower levels of inflammatory markers, and better physical performance/functioning and sleep quality. Here we describe the rationale, objectives, design, and implementation of this longitudinal epidemiologic study, compare baseline and follow-up characteristics of participants and nonparticipants, and highlight the feasibility of reexamining study participants after an extended period postbaseline with minimal interim contact.

Original languageEnglish (US)
Pages (from-to)635-644
Number of pages10
JournalAmerican journal of epidemiology
Issue number4
StatePublished - Aug 15 2013


  • cardiovascular disease
  • epidemiologic studies
  • follow-up examination
  • risk factors

ASJC Scopus subject areas

  • Epidemiology


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