From 1968 to 1978, 30 patients, age 4 to 20, with ovarian malignant growths were admitted to Roswell Park Memorial Institute. Recent advances in the treatment of childhood ovarian cancers have led to a significant improvement in survival rates. These therapeutic modalities include whole abdominal irradiation with or without mediastinal and left supraclavicular irradiation in children with ovarian dysgerminoma, the use of vincristine sulfate, actinomycin-D, and cyclophosphamide as adjunctive therapy in children with stage IA immature teratoma or endodermal sinus tumor, and high-dose methotrexate plus cyclophosphamide in metastatic epithelial ovarian cancer. In children with a unilateral ovarian stromal tumor, conservative surgery with preservation of future child-bearing potential should be carried out.
|Number of pages
|New York State Journal of Medicine
|Published - Dec 1 1979
ASJC Scopus subject areas
- General Medicine