Childhood pegboard task predicts adult-onset psychosis-spectrum disorder among a genetic high-risk sample

Pamela Rakhshan, Holger Sørensen, Jordan DeVylder, Vijay Mittal, Erik L. Mortensen, Niels M. Michelsen, Morten Ekstrøm, Steven C. Pitts, Sarnoff A. Mednick, Jason Schiffman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Motor abnormalities have been established as a core aspect of psychosis-spectrum disorders, with numerous studies identifying deficits prior to clinical symptom presentation. Additional research is needed to pinpoint standardized motor assessments associated with psychosis-spectrum disorders prior to illness onset to enhance prediction and understanding of etiology. With a long history of findings among people with diagnosable psychosis-spectrum disorders, but little research conducted during the premorbid phase, pegboard tasks are a viable and understudied measure of premorbid for psychosis motor functioning. In the current study, examining data from the Copenhagen Perinatal Cohort, the Simultaneous Pegs Test was performed with children (n = 244, aged 10–13) at genetic high risk for psychosis (n = 94) and controls (n = 150). Findings suggest that children who eventually developed a psychosis-spectrum disorder (n = 33) were less likely to successfully complete the task within time limit relative to controls (χ2 (2, N = 244) = 6.94, p = 0.03, ϕ = 0.17). Additionally, children who eventually developed a psychosis-spectrum disorder took significantly longer to complete the task relative to controls (χ2 (2, N = 244) = 7.06, p = 0.03, ϕ = 0.17). As pegboard performance is thought to tap both diffuse and specific brain networks, findings suggest that pegboard tests may be useful premorbid measures of motor functioning among those on a trajectory towards a psychosis-spectrum disorder.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalSchizophrenia Research
Volume178
Issue number1-3
DOIs
StatePublished - Dec 1 2016

Keywords

  • High-risk
  • Pegboard
  • Premorbid
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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