Chip-based high-sensitivity detection of multiple disease biomarkers

E. D. Goluch*, S. I. Savka, D. G. Georganopoulou, J. M. Nam, K. A. Shaikh, K. S. Ryu, T. N. Chiesl, A. E. Barron, C. A. Mirkin, Chang Liu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Presented in this paper is development of a protocol that employs microarrayed DNA patterns within the channels of an integrated lab-on-a-chip system. The patterned microchannels are used in conjunction with the Bio-Barcode Assay for the rapid multiplexed detection of six DNA disease biomarkers in a single experiment. The successful implementation of the Bio-Barcode Assay in a microfluidic device was further demonstrated by detecting as few as 300 prostate-specific antigen molecules in goat serum samples.

Original languageEnglish (US)
Title of host publication19th IEEE International Conference on Micro Electro Mechanical Systems
Pages478-481
Number of pages4
StatePublished - Oct 24 2006
Event19th IEEE International Conference on Micro Electro Mechanical Systems - Istanbul, Turkey
Duration: Jan 22 2006Jan 26 2006

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2006
ISSN (Print)1084-6999

Other

Other19th IEEE International Conference on Micro Electro Mechanical Systems
CountryTurkey
CityIstanbul
Period1/22/061/26/06

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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