Chlamydia pneumoniae and Atherosclerosis following Carotid Endarterectomy

Babak S. Jahromi*, Michael D. Hill, Kate Holmes, Stuart Hutchison, William S. Tucker, Brian Chiu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Seroepidemiological studies have shown an association between raised antibody titres against Chlamydia pneumoniae, and carotid atherosclerosis or stroke. However, direct evidence for a causal link between arterial infection with C. pneumoniae and carotid disease remains weak. We hypothesized that long-term follow-up of patients with pathologically-proven arterial C. pneumoniae infection might provide further insight into the role of C. pneumoniae in carotid atherosclerosis. Methods: We followed a cohort of 70 carotid endarterectomy patients for ipsilateral restenosis, contralateral progression, and all-cause mortality (four year median follow-up period). All patients had presence or absence of C. pneumoniae in their carotid plaques documented by immunohistochemistry after endarterectomy. A survival function was generated and the log-rank test was used to assess the difference in survival between subjects with and without documented chlamydial infection in their plaque. Results: Baseline demographic and cardiovascular risk factors were similar between the two groups, and survival analysis demonstrated no difference (p>0.05) in all-cause mortality, or all-cause mortality combined with restenosis and progression. Conclusions: Our data finds no causal role for C. pneumoniae in restenosis or progression of carotid disease or mortality in this patient population with advanced carotid atherosclerosis.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalCanadian Journal of Neurological Sciences
Volume30
Issue number4
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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