TY - JOUR
T1 - Chloride channels
T2 - Often enigmatic, rarely predictable
AU - Duran, Charity
AU - Thompson, Christopher H.
AU - Xiao, Qinghuan
AU - Hartzell, H. Criss
PY - 2009/3/17
Y1 - 2009/3/17
N2 - Until recently, anion (Cl-) channels have received considerably less attention than cation channels. One reason for this may be that many Cl- channels perform functions that might be considered cell-biological, like fluid secretion and cell volume regulation, whereas cation channels have historically been associated with cellular excitability, which typically happens more rapidly. In this review, we discuss the recent explosion of interest in Cl- channels, with special emphasis on new and often surprising developments over the past five years. This is exemplified by the findings that more than half of the ClC family members are antiporters, and not channels, as was previously thought, and that bestrophins, previously prime candidates for Ca{}2+{}-activated Cl- channels, have been planted by the newly discovered anoctamins and now hold a tenuous position in the Cl- channel world.
AB - Until recently, anion (Cl-) channels have received considerably less attention than cation channels. One reason for this may be that many Cl- channels perform functions that might be considered cell-biological, like fluid secretion and cell volume regulation, whereas cation channels have historically been associated with cellular excitability, which typically happens more rapidly. In this review, we discuss the recent explosion of interest in Cl- channels, with special emphasis on new and often surprising developments over the past five years. This is exemplified by the findings that more than half of the ClC family members are antiporters, and not channels, as was previously thought, and that bestrophins, previously prime candidates for Ca{}2+{}-activated Cl- channels, have been planted by the newly discovered anoctamins and now hold a tenuous position in the Cl- channel world.
KW - Anoctamin
KW - Bestrophin
KW - Channelopathies
KW - ClC
KW - Ion transport
KW - TMEM16
UR - http://www.scopus.com/inward/record.url?scp=77951782126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951782126&partnerID=8YFLogxK
U2 - 10.1146/annurev-physiol-021909-135811
DO - 10.1146/annurev-physiol-021909-135811
M3 - Review article
C2 - 19827947
AN - SCOPUS:77951782126
SN - 0066-4278
VL - 72
SP - 95
EP - 121
JO - Annual review of physiology
JF - Annual review of physiology
ER -