Choice of an optimal diluent for intravesical bacillus Calmette-Guerin administration

M. A. Hudson, W. J. Catalona, J. K. Ritchey, J. Aslanzadeh, E. J. Brown, T. L. Ratliff

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The physical conditions, including diluent pH, salt concentration and duration of bacillus Calmette-Guerin attachment, were determined in in vitro binding assays for soluble and matrix fibronectin. Since soluble fibronectin may block attachment of bacillus Calmette-Guerin to matrix fibronectin in the bladder, the optimal conditions were determined under which matrix fibronectin-bacillus Calmette-Guerin binding was maximal and soluble fibronectin-bacillus Calmette-Guerin binding was minimal. These conditions, which were confirmed in vivo in the murine bladder model, included use of normal saline, pH 7 as diluent for bacillus Calmette-Guerin organisms, with retention of the bacillus Calmette-Guerin suspension for 2 hours.

Original languageEnglish (US)
Pages (from-to)1438-1441
Number of pages4
JournalJournal of Urology
Volume142
Issue number6
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Urology

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