TY - JOUR
T1 - Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein-Barr virus
AU - Katzman, Rebecca B.
AU - Longnecker, Richard
PY - 2003/11
Y1 - 2003/11
N2 - Epstein-Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-β-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.
AB - Epstein-Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-β-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.
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U2 - 10.1099/vir.0.19252-0
DO - 10.1099/vir.0.19252-0
M3 - Article
C2 - 14573803
AN - SCOPUS:0242351756
SN - 0022-1317
VL - 84
SP - 2987
EP - 2992
JO - Journal of General Virology
JF - Journal of General Virology
IS - 11
ER -