Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein-Barr virus

Rebecca B. Katzman, Richard Longnecker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Epstein-Barr virus (EBV) infection is a multi-step process, first requiring virus binding to the host cell, followed by fusion of the viral envelope with the host cell plasma membrane. Efficient EBV entry into B cells requires, at the minimum, the interaction of the EBV-encoded glycoproteins gp350 with cellular CD21 and gp42 with MHC class II proteins. In this study, use of the cholesterol-binding drugs methyl-β-cyclodextrin and nystatin efficiently inhibited EBV infection of target Burkitt's lymphoma B-cell lines, indicating an important role for cholesterol and suggesting the involvement of lipid rafts in EBV infection.

Original languageEnglish (US)
Pages (from-to)2987-2992
Number of pages6
JournalJournal of General Virology
Issue number11
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Virology

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