The cholesteryl ester content of Erhlich cells was increased in tumors grown in mice fed saturated fat diets (coconut oil or tristearin) as compared with a polyunsaturated fat diet (sunflower oil). Cholesteryl esters containing monoenoic fatty acids were the predominant species that accumulated in the cells grown on saturated fat. The increase in cholesteryl esters was not accompanied by corresponding increases in the cell content of phospholipids, triacylglycerols,unesterified cholestorol or proteins. This experimental system may be useful for obtaining basic information about intracellular cholesteryl ester accumulation, a process that occurs in atherosclerosis.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism|
|State||Published - May 22 1975|
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