Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans)

E. J. Mufson; P. H. Desan; M. M. Mesulam; B. H. Wainer; A. I. Levey

doi:10.1016/0006-8993(84)90269-5

Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans)

E. J. Mufson^*, P. H. Desan, M. M. Mesulam, B. H. Wainer, A. I. Levey

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Choline acetyltransferase (ChAT) immunohistochemistry was used to map the cholinergic neurons in the forebrain of Pseudemys turtles. Cell bodies with ChAT-like immunoreactivity were seen in the septum, the nucleus of the diagonal band, and embedded within the medial and lateral forebrain bundles. The region of the medial and lateral forebrain bundles contained the greatest concentration of ChAT-positive neurons. Virtually no ChAT-like immunoreactivity was seen in the areas composing the reptilian homologue of the mammalian striatum. It is suggested that the turtle basal forebrain cholinergic neurons may represent the evolutionary precursors to the mammalian cholinergic neurons of the basal forebrain and even the striatum.

Original language	English (US)
Pages (from-to)	103-108
Number of pages	6
Journal	Brain research
Volume	323
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90269-5
State	Published - Dec 3 1984

Funding

We wish to thank Leah Christie, Terry Martin, Richard Plourde and Marc Peloquin for secretarial and technical assistance. This research was supported in part by grants from the Essel Foundation, the McKnight Foundation, NIH Grants NS-092tl, NS-07011, NS-17611, HD-04583, T32EY07042-05S1, the Javits Neuroscience Investigator Award NS-20285 (M.M.M.) and the ADRDA Faculty Schohtr Award (E.J.M.).

Keywords

basal forebrain
choline acetyltransferase
cholinergic
immunohistochemistry
turtle

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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title = "Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans)",

abstract = "Choline acetyltransferase (ChAT) immunohistochemistry was used to map the cholinergic neurons in the forebrain of Pseudemys turtles. Cell bodies with ChAT-like immunoreactivity were seen in the septum, the nucleus of the diagonal band, and embedded within the medial and lateral forebrain bundles. The region of the medial and lateral forebrain bundles contained the greatest concentration of ChAT-positive neurons. Virtually no ChAT-like immunoreactivity was seen in the areas composing the reptilian homologue of the mammalian striatum. It is suggested that the turtle basal forebrain cholinergic neurons may represent the evolutionary precursors to the mammalian cholinergic neurons of the basal forebrain and even the striatum.",

keywords = "basal forebrain, choline acetyltransferase, cholinergic, immunohistochemistry, turtle",

author = "Mufson, {E. J.} and Desan, {P. H.} and Mesulam, {M. M.} and Wainer, {B. H.} and Levey, {A. I.}",

note = "Funding Information: We wish to thank Leah Christie, Terry Martin, Richard Plourde and Marc Peloquin for secretarial and technical assistance. This research was supported in part by grants from the Essel Foundation, the McKnight Foundation, NIH Grants NS-092tl, NS-07011, NS-17611, HD-04583, T32EY07042-05S1, the Javits Neuroscience Investigator Award NS-20285 (M.M.M.) and the ADRDA Faculty Schohtr Award (E.J.M.).",

year = "1984",

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doi = "10.1016/0006-8993(84)90269-5",

language = "English (US)",

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AU - Mufson, E. J.

AU - Desan, P. H.

AU - Mesulam, M. M.

AU - Wainer, B. H.

AU - Levey, A. I.

N1 - Funding Information: We wish to thank Leah Christie, Terry Martin, Richard Plourde and Marc Peloquin for secretarial and technical assistance. This research was supported in part by grants from the Essel Foundation, the McKnight Foundation, NIH Grants NS-092tl, NS-07011, NS-17611, HD-04583, T32EY07042-05S1, the Javits Neuroscience Investigator Award NS-20285 (M.M.M.) and the ADRDA Faculty Schohtr Award (E.J.M.).

PY - 1984/12/3

Y1 - 1984/12/3

N2 - Choline acetyltransferase (ChAT) immunohistochemistry was used to map the cholinergic neurons in the forebrain of Pseudemys turtles. Cell bodies with ChAT-like immunoreactivity were seen in the septum, the nucleus of the diagonal band, and embedded within the medial and lateral forebrain bundles. The region of the medial and lateral forebrain bundles contained the greatest concentration of ChAT-positive neurons. Virtually no ChAT-like immunoreactivity was seen in the areas composing the reptilian homologue of the mammalian striatum. It is suggested that the turtle basal forebrain cholinergic neurons may represent the evolutionary precursors to the mammalian cholinergic neurons of the basal forebrain and even the striatum.

AB - Choline acetyltransferase (ChAT) immunohistochemistry was used to map the cholinergic neurons in the forebrain of Pseudemys turtles. Cell bodies with ChAT-like immunoreactivity were seen in the septum, the nucleus of the diagonal band, and embedded within the medial and lateral forebrain bundles. The region of the medial and lateral forebrain bundles contained the greatest concentration of ChAT-positive neurons. Virtually no ChAT-like immunoreactivity was seen in the areas composing the reptilian homologue of the mammalian striatum. It is suggested that the turtle basal forebrain cholinergic neurons may represent the evolutionary precursors to the mammalian cholinergic neurons of the basal forebrain and even the striatum.

KW - basal forebrain

KW - choline acetyltransferase

KW - cholinergic

KW - immunohistochemistry

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Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans)

Abstract

Funding

Keywords

ASJC Scopus subject areas

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