Cholinergic and non-cholinergic septohippocampal pathways

B. H. Wainer; A. I. Levey; D. B. Rye; M. M. Mesulam; E. J. Mufson

doi:10.1016/S0304-3940(85)80116-6

Cholinergic and non-cholinergic septohippocampal pathways

B. H. Wainer, A. I. Levey, D. B. Rye, M. M. Mesulam, E. J. Mufson

Neurology

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265 Scopus citations

Abstract

Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.

Original language	English (US)
Pages (from-to)	45-52
Number of pages	8
Journal	Neuroscience Letters
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(85)80116-6
State	Published - 1985

Funding

Keywords

choline acetyltransferase
cholinergic neurons
hippocampus
septohippocampal pathway
septum

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(85)80116-6

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abstract = "Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.",

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T1 - Cholinergic and non-cholinergic septohippocampal pathways

AU - Wainer, B. H.

AU - Levey, A. I.

AU - Rye, D. B.

AU - Mesulam, M. M.

AU - Mufson, E. J.

PY - 1985

Y1 - 1985

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AB - Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.

KW - choline acetyltransferase

KW - cholinergic neurons

KW - hippocampus

KW - septohippocampal pathway

KW - septum

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Cholinergic and non-cholinergic septohippocampal pathways

Abstract

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Keywords

ASJC Scopus subject areas

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