Cholinergic and non-cholinergic septohippocampal pathways

B. H. Wainer, A. I. Levey, D. B. Rye, M. M. Mesulam, E. J. Mufson

Research output: Contribution to journalArticle

256 Scopus citations

Abstract

Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalNeuroscience Letters
Volume54
Issue number1
DOIs
StatePublished - 1985

Keywords

  • choline acetyltransferase
  • cholinergic neurons
  • hippocampus
  • septohippocampal pathway
  • septum

ASJC Scopus subject areas

  • Neuroscience(all)

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