Cholinergic and non-cholinergic septohippocampal pathways

B. H. Wainer, A. I. Levey, D. B. Rye, M. M. Mesulam, E. J. Mufson

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalNeuroscience Letters
Issue number1
StatePublished - 1985


  • choline acetyltransferase
  • cholinergic neurons
  • hippocampus
  • septohippocampal pathway
  • septum

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Cholinergic and non-cholinergic septohippocampal pathways'. Together they form a unique fingerprint.

Cite this