Cholinergic denervation in a pure multi-infarct state: Observations on CADASIL

Marsel Mesulam*, Teepu Siddique, Bruce Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


Circumstantial evidence suggests that vascular dementia (VaD) may be associated with cholinergic denervation. The specificity of this association has been difficult to assess because many of the patients are elderly and have the additional cholinergic lesions of aging and AD. A patient with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) who died at age 36 showed that pure white matter infarcts, similar to those seen in VaD, can cause cortical cholinergic denervation, but in patterns that vary from those seen in AD.

Original languageEnglish (US)
Pages (from-to)1183-1185
Number of pages3
Issue number7
StatePublished - Apr 8 2003

ASJC Scopus subject areas

  • Clinical Neurology


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