Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry

E. J. Mufson*, T. L. Martin, D. C. Mash, B. H. Wainer, M. M. Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Choline acetyltransferase (ChAT) immunocytochemistry, acetylcholinesterase histochemistry and muscarinic receptor autoradiography demonstrated a cholinergic innervation within the superior colliculus. A method for the concurrent visualization of ChAT and transported horseradish peroxidase showed that a major extrinsic source for this cholinergic input is in the parabigeminal nucleus. We have designated these cholinergic neurons as the Ch8 cell group.

Original languageEnglish (US)
Pages (from-to)144-148
Number of pages5
JournalBrain research
Volume370
Issue number1
DOIs
StatePublished - Apr 2 1986

Funding

We wish to thank Leah Christie and Richard Plourde for expert secretarial and photographic assistance. Supported in part by the ADRDA Faculty Scholar Award (E.J.M.), the Javits Neuroscience Investigator Award, the McKnight Foundation, an Alzheimer's Research Center NIA AG-05134, NS-17661, NS-07211 and HD-04583.

Keywords

  • choline acetyltransferase
  • cholinergic
  • horseradish peroxidase
  • immunohistochemistry
  • mouse
  • superior coliculus

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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