Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry

E. J. Mufson; T. L. Martin; D. C. Mash; B. H. Wainer; M. M. Mesulam

doi:10.1016/0006-8993(86)91114-5

Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry

E. J. Mufson^*, T. L. Martin, D. C. Mash, B. H. Wainer, M. M. Mesulam

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Choline acetyltransferase (ChAT) immunocytochemistry, acetylcholinesterase histochemistry and muscarinic receptor autoradiography demonstrated a cholinergic innervation within the superior colliculus. A method for the concurrent visualization of ChAT and transported horseradish peroxidase showed that a major extrinsic source for this cholinergic input is in the parabigeminal nucleus. We have designated these cholinergic neurons as the Ch8 cell group.

Original language	English (US)
Pages (from-to)	144-148
Number of pages	5
Journal	Brain research
Volume	370
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91114-5
State	Published - Apr 2 1986

Funding

We wish to thank Leah Christie and Richard Plourde for expert secretarial and photographic assistance. Supported in part by the ADRDA Faculty Scholar Award (E.J.M.), the Javits Neuroscience Investigator Award, the McKnight Foundation, an Alzheimer's Research Center NIA AG-05134, NS-17661, NS-07211 and HD-04583.

Keywords

choline acetyltransferase
cholinergic
horseradish peroxidase
immunohistochemistry
mouse
superior coliculus

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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Mufson, E. J., Martin, T. L., Mash, D. C., Wainer, B. H., & Mesulam, M. M. (1986). Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry. Brain research, 370(1), 144-148. https://doi.org/10.1016/0006-8993(86)91114-5

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title = "Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry",

abstract = "Choline acetyltransferase (ChAT) immunocytochemistry, acetylcholinesterase histochemistry and muscarinic receptor autoradiography demonstrated a cholinergic innervation within the superior colliculus. A method for the concurrent visualization of ChAT and transported horseradish peroxidase showed that a major extrinsic source for this cholinergic input is in the parabigeminal nucleus. We have designated these cholinergic neurons as the Ch8 cell group.",

keywords = "choline acetyltransferase, cholinergic, horseradish peroxidase, immunohistochemistry, mouse, superior coliculus",

author = "Mufson, \{E. J.\} and Martin, \{T. L.\} and Mash, \{D. C.\} and Wainer, \{B. H.\} and Mesulam, \{M. M.\}",

note = "Funding Information: We wish to thank Leah Christie and Richard Plourde for expert secretarial and photographic assistance. Supported in part by the ADRDA Faculty Scholar Award (E.J.M.), the Javits Neuroscience Investigator Award, the McKnight Foundation, an Alzheimer's Research Center NIA AG-05134, NS-17661, NS-07211 and HD-04583.",

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doi = "10.1016/0006-8993(86)91114-5",

language = "English (US)",

volume = "370",

pages = "144--148",

journal = "Brain research",

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publisher = "Elsevier B.V.",

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Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry. / Mufson, E. J.; Martin, T. L.; Mash, D. C. et al.
In: Brain research, Vol. 370, No. 1, 02.04.1986, p. 144-148.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse

T2 - a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry

AU - Mufson, E. J.

AU - Martin, T. L.

AU - Mash, D. C.

AU - Wainer, B. H.

AU - Mesulam, M. M.

N1 - Funding Information: We wish to thank Leah Christie and Richard Plourde for expert secretarial and photographic assistance. Supported in part by the ADRDA Faculty Scholar Award (E.J.M.), the Javits Neuroscience Investigator Award, the McKnight Foundation, an Alzheimer's Research Center NIA AG-05134, NS-17661, NS-07211 and HD-04583.

PY - 1986/4/2

Y1 - 1986/4/2

N2 - Choline acetyltransferase (ChAT) immunocytochemistry, acetylcholinesterase histochemistry and muscarinic receptor autoradiography demonstrated a cholinergic innervation within the superior colliculus. A method for the concurrent visualization of ChAT and transported horseradish peroxidase showed that a major extrinsic source for this cholinergic input is in the parabigeminal nucleus. We have designated these cholinergic neurons as the Ch8 cell group.

AB - Choline acetyltransferase (ChAT) immunocytochemistry, acetylcholinesterase histochemistry and muscarinic receptor autoradiography demonstrated a cholinergic innervation within the superior colliculus. A method for the concurrent visualization of ChAT and transported horseradish peroxidase showed that a major extrinsic source for this cholinergic input is in the parabigeminal nucleus. We have designated these cholinergic neurons as the Ch8 cell group.

KW - choline acetyltransferase

KW - cholinergic

KW - horseradish peroxidase

KW - immunohistochemistry

KW - mouse

KW - superior coliculus

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Cholinergic projections from the parabigeminal nucleus (Ch8) to the superior colliculus in the mouse: a combined analysis of horseradish peroxidase transport and choline acetyltransferase immunohistochemistry

Abstract

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Keywords

ASJC Scopus subject areas

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