Cholinesterase activity in the plaques, tangles and angiopathy of Alzheimer's disease does not emanate from amyloid

Changiz Geula*, Barry D. Greenberg, M. Marsel Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Previous histochemical observations in our laboratory have demonstrated the presence of butyrylcholinesterase and an enzymatically altered form of acetylcholinesterase activity in the plaques, tangles and amyloid-containing vessels of Alzheimer's disease. These findings suggested possible interactions between amyloid and cholinesterases. In this study we employed a cholinesterase biochemical assay to determine whether the amyloid precursor protein either had cholinesterase activity itself or influenced the enzymatic activity of cholinesterases. None of the three amyloid precursor sequences used (695, 751, 770, up to 16 μg/ml) exhibited any acetylcholinesterase or butyrylcholinesterase activity that could be detected by our method. In addition, none of the amyloid precursor proteins influenced the enzymatic activity of purified acetylcholinesterase or butyrylcholinesterase in a specific manner. It is therefore quite unlikely that amyloid can, by itself, account for the intense cholinesterase activity associated with the pathological lesions of AD.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalBrain research
Volume644
Issue number2
DOIs
StatePublished - May 2 1994

Keywords

  • Alzheimer's disease
  • Amyloid precursor protein
  • Cholinesterases
  • Plaque
  • Tangle

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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