Cholinesterases in the amyloid angiopathy of Alzheimer's disease

Marsel Mesulam*, Keith Carson, Bruce Price, Changiz Geula

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Vessels affected by amyloid angiopathy in patients with Alzheimer's disease also displayed intense acetylcholinestearase and butyrylcholinesterase activity when examined by light and electron microscopy. The enzymatic properties of the vessel‐bound cholinesterases were identical to those of the cholinesterases associated with senile plaques and neurofibrillary tangles. This cholinesterase activity is of unknown origin but represents one of the very few features common to all the major pathological markers of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalAnnals of neurology
Volume31
Issue number5
DOIs
StatePublished - May 1992

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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