Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

M‐Marsel ‐M Mesulam; M. Asuncion Morán

doi:10.1002/ana.410220206

Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

M‐Marsel ‐M Mesulam^*, M. Asuncion Morán

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two enzymes were differentially distributed. In other areas, there was a very close overlap between the two types of cholinesterase.

Original language	English (US)
Pages (from-to)	223-228
Number of pages	6
Journal	Annals of neurology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/ana.410220206
State	Published - Aug 1987

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease",

abstract = "Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two enzymes were differentially distributed. In other areas, there was a very close overlap between the two types of cholinesterase.",

author = "Mesulam, {M‐Marsel ‐M} and {Asuncion Mor{\'a}n}, M.",

year = "1987",

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N2 - Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two enzymes were differentially distributed. In other areas, there was a very close overlap between the two types of cholinesterase.

AB - Enzyme histochemistry showed that a substantial number of cortical neurofibrillary tangles contain acetylcholinesterase and butyrylcholinesterase activities in patients with Alzheimer's disease and in nondemented aged individuals. In some areas of the brain, tangles containing each of these two enzymes were differentially distributed. In other areas, there was a very close overlap between the two types of cholinesterase.

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Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

Abstract

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