Choroidal amyloidosis: a case report

Amyloidosis can affect many ocular and periocular structures including the eyelids, conjunctiva, orbit, cornea, pupil, vitreous, and retina. Many reports have emphasized involvement of the vitreous, which may be visually disabling and may require vitrectomy. Histologic involvement of the choroid has been noted occasionally. This report describes the clinical and histopathologic findings in a patient with primary (sporadic) generalized amyloidosis with choroidal deposition of amyloid in the posterior pole; no involvement of the retinal blood vessels was seen. In spite of extensive occlusion of the choriocapillaris, visual acuity was normal, the patient was asymptomatic and the overlying retina was apparently morphologically normal. The light and electron microscopic findings in this patient are described.