Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression

Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

817 Scopus citations

Abstract

It is more evident now than ever that nucleosomes can transmit epigenetic information from one cell generation to the next. It has been demonstrated during the past decade that the posttranslational modifications of histone proteins within the chromosome impact chromatin structure, gene transcription, and epigenetic information. Multiple modifications decorate each histone tail within the nucleosome, including some amino acids that can be modified in several different ways. Covalent modifications of histone tails known thus far include acetylation, phosphorylation, sumoylation, ubiquitination, and methylation. A large body of experimental evidence compiled during the past several years has demonstrated the impact of histone acetylation on transcriptional control. Although histone modification by methylation and ubiquitination was discovered long ago, it was only recently that functional roles for these modifications in transcriptional regulation began to surface. Highlighted in this review are the recent biochemical, molecular, cellular, and physiological functions of histone methylation and ubiquitination involved in the regulation of gene expression as determined by a combination of enzymological, structural, and genetic methodologies.

Original languageEnglish (US)
Pages (from-to)243-269
Number of pages27
JournalAnnual review of biochemistry
Volume75
DOIs
StatePublished - 2006

Keywords

  • Epigenetic regulation
  • Histone methylation
  • Histone ubiquitination
  • MLL
  • Transcriptional elongation

ASJC Scopus subject areas

  • Biochemistry

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