Chromatin reprogramming via contact guidance-induced nuclear deformation promotes stem cell differentiation

Vasundhara Agrawal*, Xinlong Wang, Yue Li, Ranya K.A. Virk, Priyam A. Patel, Surbhi Jain, Nancy Rivera-Bolanos, Jane Frederick, Eric Roth, Reiner Bleher, Chongwen Duan, Bin Jiang, Panagiotis Ntziachristos, Vadim Backman, Guillermo A. Ameer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using chromatin packing macromolecular crowding (CPMC) model predictions and nanoscale imaging and sequencing studies, we demonstrate that micropillar structures enhance osteogenic differentiation by decreasing chromatin packing scaling in hMSCs and consequently increasing lineage-specific responsiveness.

Original languageEnglish (US)
Title of host publicationBio-Optics
Subtitle of host publicationDesign and Application, BODA 2021
PublisherOptica Publishing Group (formerly OSA)
ISBN (Electronic)9781557528209
StatePublished - 2021
EventBio-Optics: Design and Application, BODA 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 - Virtual, Online, United States
Duration: Apr 12 2021Apr 16 2021

Publication series

NameOptics InfoBase Conference Papers

Conference

ConferenceBio-Optics: Design and Application, BODA 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021
Country/TerritoryUnited States
CityVirtual, Online
Period4/12/214/16/21

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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