Chromatin signatures of cancer

Marc A. Morgan, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of genomic stability. Studies by cancer genome consortiums have identified frequent mutations in genes encoding chromatin regulatory factors and histone proteins in human cancer, implicating them as major mediators in the pathogenesis of both hematological malignancies and solid tumors. Here, we review recent advances in our understanding of the role of chromatin in cancer, focusing on transcriptional regulatory complexes, enhancer-associated factors, histone point mutations, and alterations in heterochromatin-interacting factors.

Original languageEnglish (US)
Pages (from-to)238-249
Number of pages12
JournalGenes and Development
Volume29
Issue number3
DOIs
StatePublished - 2015

Keywords

  • Cancer
  • Chromatin
  • Histone proteins

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Fingerprint Dive into the research topics of 'Chromatin signatures of cancer'. Together they form a unique fingerprint.

Cite this