Chromatin's physical properties shape the nucleus and its functions

Andrew D. Stephens, Edward J. Banigan, John F. Marko

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton. Abnormal nuclear shape is a diagnostic marker for human diseases, and it can cause nuclear dysfunction. Chromatin mechanics underlies this link, as alterations to chromatin and its physical properties can disrupt or rescue nuclear shape. The cell can regulate nuclear shape through mechanotransduction pathways that sense and respond to extracellular cues, thus modulating chromatin compaction and rigidity. These findings reveal how chromatin's physical properties can regulate cellular function and drive abnormal nuclear morphology and dysfunction in disease.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume58
DOIs
StatePublished - Jun 2019

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ASJC Scopus subject areas

  • Cell Biology

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