TY - JOUR
T1 - Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes
AU - WATANABE, TOSHIO
AU - MUKOUYAMA, YOUSUKE
AU - RHODES, MICHAEL
AU - THOMAS, MATTHEW
AU - KUME, TSUTOMU
AU - OISHI, MICHIO
N1 - Funding Information:
We thank Dr. Davor Solter (Max-Planck Institute of Immunbiol-ogy) for his valuable comments. The research was supported partly by a Grant-in-Aid for Scienti®c Research from the Ministry of Education, Science and Culture of Japan.
PY - 1995/10
Y1 - 1995/10
N2 - It is now widely accepted that protein tyrosine phosphatases (PTPases) play important or even critical roles in cell growth, differentiation, and development. Our recent experiments suggested that specific PTPases, PTPβ2 and PTPε, are involved in the early molecular events forin vitrodifferentiation of mouse erythroleukemia (MEL) as well as embryonic carcinoma (F9) cells. Using mouse cDNA for PTPβ2 and PTPε, which we have cloned recently, we attempted to locate the genes to mouse chromosomes. Interspecific backcross analysis indicated that the gene for PTPβ2, Ptprj, is located in the middle region of chromosome 2, and the gene for PTPε, Ptpre, was mapped in the vicinity of the imprinted regions in the distal part of chromosome 7. Possible biological roles of these PTPases are discussed.
AB - It is now widely accepted that protein tyrosine phosphatases (PTPases) play important or even critical roles in cell growth, differentiation, and development. Our recent experiments suggested that specific PTPases, PTPβ2 and PTPε, are involved in the early molecular events forin vitrodifferentiation of mouse erythroleukemia (MEL) as well as embryonic carcinoma (F9) cells. Using mouse cDNA for PTPβ2 and PTPε, which we have cloned recently, we attempted to locate the genes to mouse chromosomes. Interspecific backcross analysis indicated that the gene for PTPβ2, Ptprj, is located in the middle region of chromosome 2, and the gene for PTPε, Ptpre, was mapped in the vicinity of the imprinted regions in the distal part of chromosome 7. Possible biological roles of these PTPases are discussed.
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U2 - 10.1006/geno.1995.9932
DO - 10.1006/geno.1995.9932
M3 - Article
C2 - 8575779
AN - SCOPUS:0028856890
SN - 0888-7543
VL - 29
SP - 793
EP - 795
JO - Genomics
JF - Genomics
IS - 3
ER -