Chromosomal sex and distribution of functional germ cells in a series of chimeric mice

P. M. Iannaccone*, E. P. Evans, M. D. Burtenshaw

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

An unselected series of chimeric mice were test mated to determine the parental lineage of their functional gametes. The cytological sex of each animal was established and confirmed in all cases by karyological analysis of peripheral blood lymphocytes. The parental cell lineage for each cytological sex was unequivocally established by the presence or absence of the radiation-induced translocation 1514 (T6). Eleven animals were analysed, 10 of these were chimeric. Among the 10 chimeras, 3 were phenotypically female and 7 were phenotypically male. The cytological sex ratio (XY/XY:XX/XY:XX/XX) was 1:6:2. There were 646 offspring from test matings of these chimeras. The coat color analysis of these offspring demonstrated a concordance of cytological sex of the lineage resulting in functional gametes with the phenotypic sex of the animal.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalExperimental Cell Research
Volume156
Issue number2
DOIs
StatePublished - Feb 1985

ASJC Scopus subject areas

  • Cell Biology

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